Maître de Conférences
Mail : viviane.silva-pires@u-picardie.fr
Tél : Non renseigné
Fax : Non renseigné
C.V.

Membre de l'équipe THERA

Thématique:

Synthèse de molécules hétérocycliques, peptidiques ou macrocycliques à visée thérapeutique

Description des travaux de recherche

La première thématique concerne la synthèse de peptides et de peptidomimétiques à visée anti-thrombotiques et anti-angiogénique. La deuxième thématique consiste en l’obtention de macrocycles de structure calix[4]arènes ou de structures mixte résultant de couplage phénol-hétérocyclique azoté. Plusieurs applications de ces dérivés sont envisagées. A titre d’exemple : vectorisation de médicaments ou/et recherche de nouveaux chélateurs du Fer à visée antiproliférative par incorporation de motifs variés pouvant être de type peptidiques ou hydroxamates. Ces derniers devraient permettre, en effet, de disposer de complexants du fer possédant une bonne balance hydrophile-lipophile compatible avec leur utilisation thérapeutique. La dernière thématique a pour but l’identification, la caractérisation et l’hémi-synthèse de produits d’origine naturelle à visée antipaludique notamment.

 

Mots Clés :

peptides, calixarènes, triterpènes, anti-angiogénique, chélateurs du fer, vectorisation, antipaludique

 

Publications

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  [1] P. Sonnet, C. Mullie, In vitro antimalarial activity of ICL670: A further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin, Exp. Parasitol., 128 (2011) 26-31.
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  [2] P. Rouge, M. Becuwe, A. Dassonville-Klimpt, S. Fardeau, N.S. Da, J.-F. Raimbert, D. Cailleu, E. Baudrin, P. Sonnet, Efficient synthesis of amino-protected calix[4]arenes selectively functionalized with iron chelator ICL670 designed as platform for iron recognition, in, American Chemical Society, 2011, pp. MEDI-106.
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  [3] P. Rouge, M. Becuwe, A. Dassonville-Klimpt, N.S. Da, J.-F. Raimbert, D. Cailleu, E. Baudrin, P. Sonnet, Efficient synthesis of amino-protected calix[4]arenes selectively functionalized with iron chelator ICL670 designed as platform for iron recognition, Tetrahedron, 67 (2011) 2916-2924.
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  [4] V.S. Pires, N.S. Da, S. Fardeau, P. Sonnet, Synthesis of 4-thiouracil KPGEPGPK analogs as TIIICBP identification tools, in, American Chemical Society, 2011, pp. MEDI-107.
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  [5] A. Jonet, A. Dassonville-Klimpt, S. Fardeau, N. Taudon, P. Sonnet, Synthesis of enantiopur antimalarial 4-aminoquinolinols, in, American Chemical Society, 2011, pp. MEDI-105.
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  [6] A. Jonet, A. Dassonville-Klimpt, N.S. Da, J.-M. Leger, J. Guillon, P. Sonnet, First enantioselective synthesis of 4-aminoalcohol quinoline derivatives through a regioselective SN2 epoxide opening mechanism, Tetrahedron: Asymmetry, 22 (2011) 138-148.
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  [7] S. Fardeau, C. Demailly-Mullie, A. Dassonville-Klimpt, N. Audic, P. Sonnet, Bacterial iron's uptake: A promising solution against multidrug resistant bacteria, in, American Chemical Society, 2011, pp. MEDI-108.
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  [8] P. Rouge, V.S. Pires, F. Gaboriau, A. Dassonville-Klimpt, J. Guillon, N.S. Da, J.-M. Leger, G. Lescoat, P. Sonnet, Antiproliferative effect on HepaRG cell cultures of new calix
  [4]arenes, J. Enzyme Inhib. Med. Chem., 25 (2010) 216-227.
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  [9] P. Rouge, M. Becuwe, A. Dassonville-Klimpt, A. Jonet, M. Benazza, C. Guery, E. Baudrin, P. Sonnet, Synthesis of new hybrid materials designed for iron selective electrodes based on selective amino spacer organizations, in, American Chemical Society, 2010, pp. MEDI-433.
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  [10] V.S. Pires, N.S. da, P. Sonnet, Synthesis of 4-thiouracil KPGEPGPK analogues as potential TIIICBP identification tools, Int. J. Pept. Res. Ther., 16 (2010) 257-266.
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  [11] A. Jonet, A. Dassonville-Klimpt, P. Sonnet, Synthesis of new antimalarial bi-drug molecules, in, American Chemical Society, 2010, pp. MEDI-143.
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  [12] S. Fardeau, A. Jonet, A. Dassonville-Klimpt, N. Audic, P. Sonnet, "Trojan horse" strategy: An efficient therapy against multidrug resistance bacteria, in, American Chemical Society, 2010, pp. MEDI-322.
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  [13] P. Rouge, P.V. Silva, F. Gaboriau, A. Dassonville-Klimpt, P. Sonnet, Synthesis and antiproliferative effect of new iron (III) chelators calix
  [4]arenes, in, American Chemical Society, 2009, pp. ORGN-189.
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  [14] P. Rouge, A. Dassonville-Klimpt, M. Benazza, C. Guery, E. Baudrin, P. Sonnet, Development of new hybrid materials for iron selective electrodes, in, American Chemical Society, 2009, pp. ORGN-135.
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  [15] J. Pecher, V. Pires, I. Djaafri, N.S. Da, F. Fauvel-Lafeve, C. Legrand, P. Sonnet, Circular dichroism studies of type III collagen mimetic peptides with anti- or pro-aggregant activities on human platelets, Eur. J. Med. Chem., 44 (2009) 2643-2650.
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  [16] C.L. Lencina, A. Dassonville-Klimpt, P. Sonnet, New efficient enantioselective synthesis of 2-oxopiperazines: a practical access to chiral 3-substituted 2-oxopiperazines, Tetrahedron: Asymmetry, 19 (2008) 1689-1697.
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  [17] C. Cezard, E. Vanquelef, J. Pecher, P. Sonnet, P. Cieplak, E. Derat, F.-Y. Dupradeau, RESP charge derivation and force field topology database generation for complex bio-molecular systems and analogs, in, American Chemical Society, 2008, pp. COMP-267.
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  [18] V. Pires, J. Pecher, N.S. Da, P. Maurice, A. Bonnefoy, A. Dassonville, C. Amant, F. Fauvel-Lafeve, C. Legrand, J. Rochette, P. Sonnet, Type III collagen mimetic peptides designed with anti- or pro-aggregant activities on human platelets, Eur. J. Med. Chem., 42 (2007) 694-701.
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  [19] V.S. Pires, F. Gaboriau, J. Guillon, N.S. Da, A. Dassonville, G. Lescoat, V. Desplat, J. Rochette, C. Jarry, P. Sonnet, Modulation of cell proliferation in rat liver cell cultures by new calix
  [4]arenes, J. Enzyme Inhib. Med. Chem., 21 (2006) 261-270.
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  [20] N. Franceschini, P. Sonnet, D. Guillaume, Simple, versatile and highly diastereoselective synthesis of 1,3,4-trisubstituted-2-oxopiperazine-containing peptidomimetic precursors, Org. Biomol. Chem., 3 (2005) 787-793.
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  [21] P. Sonnet, N.S. Da, D. Marty, N. Franceschini, J. Guillon, J.-D. Brion, J. Rochette, First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity, Tetrahedron Lett., 44 (2003) 3293-3296.
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  [22] N. Franceschini, N.S. Da, P. Sonnet, D. Guillaume, Efficient enantioselective synthesis of 2-substituted thiomorpholin-3-ones, Tetrahedron: Asymmetry, 14 (2003) 3401-3405.
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  [23] P. Sonnet, L. Petit, D. Marty, J. Guillon, J. Rochette, J.D. Brion, First synthesis of segetalin A and analogous cyclohexapeptides, Tetrahedron Lett., 42 (2001) 1681-1683.