Professeur
Mail : pascal.sonnet@u-picardie.fr
Tel : +33(0)3 22 82 74 84
Fax : non renseigné
C.V.

 

Responsable de l'équipe THERA

 

Thématique

Synthèse de molécules hétérocycliques, peptidiques ou macrocycliques à visée thérapeutique

Description des travaux de recherche

Les travaux de recherche développés s’orientent selon trois thématiques principales qui font appel à la chimie peptidique, hétérocyclique et macrocyclique mais aussi à la chimie inorganique et à la biologie ce qui implique de nombreuses collaborations scientifiques. La première thématique étudiée s’intéresse à des peptides ou des peptidomimétiques à activité anti-angiogénique. La deuxième thématique consiste en l’obtention de macrocycles de structure calix[4]arène ou de structure mixte résultant de couplage phénol-hétérocycle azoté. Ces macrocycles peuvent être greffés sur des supports inorganiques en vue d’application chimique de type catalyse chimique ou en vue d’obtenir des biocapteurs (chélateurs du Fer). La dernière thématique a pour but de disposer de nouvelles molécules antimicrobiennes (bi-drogues comportant un chélateur du Fer et/ou noyau pipérazinique) efficaces et sélectives afin de combattre les phénomènes de résistance.

Mots Clés : hétérocycles azotés, pipérazines, calixarènes, peptidomimétiques, calixarènes, chélateurs du fer, antiangiogénique, antipaludique.

 Publications

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  [1] P. Sonnet, C. Mullie, In vitro antimalarial activity of ICL670: A further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin, Exp. Parasitol., 128 (2011) 26-31.
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  [2] P. Rouge, M. Becuwe, A. Dassonville-Klimpt, S. Fardeau, N.S. Da, J.-F. Raimbert, D. Cailleu, E. Baudrin, P. Sonnet, Efficient synthesis of amino-protected calix[4]arenes selectively functionalized with iron chelator ICL670 designed as platform for iron recognition, in, American Chemical Society, 2011, pp. MEDI-106.
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  [3] P. Rouge, M. Becuwe, A. Dassonville-Klimpt, N.S. Da, J.-F. Raimbert, D. Cailleu, E. Baudrin, P. Sonnet, Efficient synthesis of amino-protected calix[4]arenes selectively functionalized with iron chelator ICL670 designed as platform for iron recognition, Tetrahedron, 67 (2011) 2916-2924.
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  [4] V.S. Pires, N.S. Da, S. Fardeau, P. Sonnet, Synthesis of 4-thiouracil KPGEPGPK analogs as TIIICBP identification tools, in, American Chemical Society, 2011, pp. MEDI-107.
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  [5] A. Jonet, A. Dassonville-Klimpt, S. Fardeau, N. Taudon, P. Sonnet, Synthesis of enantiopur antimalarial 4-aminoquinolinols, in, American Chemical Society, 2011, pp. MEDI-105.
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  [6] A. Jonet, A. Dassonville-Klimpt, N.S. Da, J.-M. Leger, J. Guillon, P. Sonnet, First enantioselective synthesis of 4-aminoalcohol quinoline derivatives through a regioselective SN2 epoxide opening mechanism, Tetrahedron: Asymmetry, 22 (2011) 138-148.
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  [7] S. Fardeau, C. Demailly-Mullie, A. Dassonville-Klimpt, N. Audic, P. Sonnet, Bacterial iron's uptake: A promising solution against multidrug resistant bacteria, in, American Chemical Society, 2011, pp. MEDI-108.
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  [8] P. Rouge, V.S. Pires, F. Gaboriau, A. Dassonville-Klimpt, J. Guillon, N.S. Da, J.-M. Leger, G. Lescoat, P. Sonnet, Antiproliferative effect on HepaRG cell cultures of new calix
  [4]arenes, J. Enzyme Inhib. Med. Chem., 25 (2010) 216-227.
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  [9] P. Rouge, M. Becuwe, A. Dassonville-Klimpt, A. Jonet, M. Benazza, C. Guery, E. Baudrin, P. Sonnet, Synthesis of new hybrid materials designed for iron selective electrodes based on selective amino spacer organizations, in, American Chemical Society, 2010, pp. MEDI-433.
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  [10] V.S. Pires, N.S. da, P. Sonnet, Synthesis of 4-thiouracil KPGEPGPK analogues as potential TIIICBP identification tools, Int. J. Pept. Res. Ther., 16 (2010) 257-266.
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  [11] A. Jonet, A. Dassonville-Klimpt, P. Sonnet, Synthesis of new antimalarial bi-drug molecules, in, American Chemical Society, 2010, pp. MEDI-143.
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  [12] S. Fardeau, A. Jonet, A. Dassonville-Klimpt, N. Audic, P. Sonnet, "Trojan horse" strategy: An efficient therapy against multidrug resistance bacteria, in, American Chemical Society, 2010, pp. MEDI-322.
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  [13] P. Rouge, P.V. Silva, F. Gaboriau, A. Dassonville-Klimpt, P. Sonnet, Synthesis and antiproliferative effect of new iron (III) chelators calix
  [4]arenes, in, American Chemical Society, 2009, pp. ORGN-189.
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  [14] P. Rouge, A. Dassonville-Klimpt, M. Benazza, C. Guery, E. Baudrin, P. Sonnet, Development of new hybrid materials for iron selective electrodes, in, American Chemical Society, 2009, pp. ORGN-135.
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  [15] J. Pecher, V. Pires, I. Djaafri, N.S. Da, F. Fauvel-Lafeve, C. Legrand, P. Sonnet, Circular dichroism studies of type III collagen mimetic peptides with anti- or pro-aggregant activities on human platelets, Eur. J. Med. Chem., 44 (2009) 2643-2650.
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  [16] C.L. Lencina, A. Dassonville-Klimpt, P. Sonnet, New efficient enantioselective synthesis of 2-oxopiperazines: a practical access to chiral 3-substituted 2-oxopiperazines, Tetrahedron: Asymmetry, 19 (2008) 1689-1697.
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  [17] C. Cezard, E. Vanquelef, J. Pecher, P. Sonnet, P. Cieplak, E. Derat, F.-Y. Dupradeau, RESP charge derivation and force field topology database generation for complex bio-molecular systems and analogs, in, American Chemical Society, 2008, pp. COMP-267.
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  [18] V. Pires, J. Pecher, N.S. Da, P. Maurice, A. Bonnefoy, A. Dassonville, C. Amant, F. Fauvel-Lafeve, C. Legrand, J. Rochette, P. Sonnet, Type III collagen mimetic peptides designed with anti- or pro-aggregant activities on human platelets, Eur. J. Med. Chem., 42 (2007) 694-701.
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  [19] V.S. Pires, F. Gaboriau, J. Guillon, N.S. Da, A. Dassonville, G. Lescoat, V. Desplat, J. Rochette, C. Jarry, P. Sonnet, Modulation of cell proliferation in rat liver cell cultures by new calix
  [4]arenes, J. Enzyme Inhib. Med. Chem., 21 (2006) 261-270.
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  [20] N. Franceschini, P. Sonnet, D. Guillaume, Simple, versatile and highly diastereoselective synthesis of 1,3,4-trisubstituted-2-oxopiperazine-containing peptidomimetic precursors, Org. Biomol. Chem., 3 (2005) 787-793.
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  [21] P. Sonnet, N.S. Da, D. Marty, N. Franceschini, J. Guillon, J.-D. Brion, J. Rochette, First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity, Tetrahedron Lett., 44 (2003) 3293-3296.
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  [22] N. Franceschini, N.S. Da, P. Sonnet, D. Guillaume, Efficient enantioselective synthesis of 2-substituted thiomorpholin-3-ones, Tetrahedron: Asymmetry, 14 (2003) 3401-3405.
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  [23] P. Sonnet, L. Petit, D. Marty, J. Guillon, J. Rochette, J.D. Brion, First synthesis of segetalin A and analogous cyclohexapeptides, Tetrahedron Lett., 42 (2001) 1681-1683.