Professeur
Mail : florence.pilard@u-picardie.fr
Tel : 03 22 82 75 62
Fax : 03 22 82 75 62
C.V.

Directrice de l'UMR

Responsable de l'équipe SUPRA

Description des travaux de recherche

Une grande part de l'activité est  axée sur la modification chimique de cyclodextrines, leur caractérisation complète et leurs applications ce qui implique de nombreuses collaborations scientifiques (académiques ou industrielles).  Des applications peuvent être envisagées par le biais de la formation de ces  nouvelles supramolécules et quelques approches  sont en cours de développement au Laboratoire: Solubilisation, Protection  et Promotion d'absorption cutanée par des cyclodextrines modifiées, Synthèse et Etude de cyclodextrines modifiées, portant un signal spécifique d'un récepteur, Le greffage d'un groupement hydrophobe sur la cyclodextrine afin de rendre celle-ci amphiphile pour former de nouveaux  systèmes organisés. Enfin, la synthèse et la fonctionnalisation d'oligosaccharides bioactifs (mimes de N-glycanes, oligosaccharides d'origine végétale) en utilisant des voies de synthèses originales (multiglycosylations régioselectives, acétolyse de cyclodextrines fonctionnalisées est en cours de développement.

Publications

• Inclusion complex of n-octyl β-D-glucopyranoside and α-cyclodextrin in aqueous solutions: thermodynamic and structural characterization.
  V. BERNAT, C. RINGARD-LEFEBVRE, G. LE BAS, B. PERLY, F. DJEDAINI-PILARD, S. LESIEUR.
  Langmuir : the ACS journal of surfaces and colloids, 2008, 24(7), 3140-9.

• Physico-chemical investigation of asymmetrical peptidolipidyl-cyclodextrins.
  A. ANGELOVA, C. FAJOLLES, C. HOCQUELET, F. DJEDAINI-PILARD, S. LESIEUR, V. BONNET, B. PERLY.
  Journal of Colloid and Interface Science, 2008, 322(1), 304-314.

• Lipid lateral segregation driven by diacyl cyclodextrin interactions at the membrane surface.
  M. ROUX, S. MOUTARD, B. PERLY, F. DJEDAINI-PILARD.
  Biophysical Journal, 2007, 93(5), 1620-1629.
  Erratum, Biophysical Journal, 2008, 94(2), 715.

• Self-assemblies of amphiphilic cyclodextrins.
  M. ROUX, B. PERLY, F. DJEDAINI-PILARD.
  European Biophysics Journal, 2007, 36(8), 861-867.

• Cyclodextrins and Their Complexes, Chemistry, Analytical Methods, Applications edited by Helena Dodziuk.
  F. DJEDAINI-PILARD, V. BONNET.
  Angewandte Chemie, International Edition, 2007, 46(14), 2352-2353.

• Direct synthesis of novel amphiphilic cyclodextrin.
  D. GALLOIS-MONTBRUN, N. THIEBAULT, V. MOREAU, G. LE BAS, J.-C. ARCHAMBAULT, S. LESIEUR, F. DJEDAINI-PILARD.
  Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2007, 57(1-4), 131-135.

• Oligosaccharide tagged β-cyclodextrins: synthesis and biological affinity towards Concanavalin A.
  N. SMILJANIC, V. MOREAU, D. YOCKOT, J. M. GARCIA FERNÀNDEZ, F. DJEDAINI-PILARD.
  Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2007, 57(1-4), 9-14.

• Novel chemo-enzymatic access to amphiphilic cyclodextrins.
  A. FAVRELLE, V. BONNET, C. SARAZIN, F. DJEDAINI-PILARD.
  Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2007, 57(1-4), 15-20.

• Supramolecular control of oligosaccharide-protein interactions: switchable and tunable ligands for concanavalin A based on β-cyclodextrin.
  N. SMILJANIC, V. MOREAU, D. YOCKOT, J. M. BENITO, J. M. GARCIA FERNÀNDEZ, F. DJEDAINI-PILARD.
  Angewandte Chemie, International Edition, 2006, 45(33), 5465-5468.

• Electrospray ionization mass spectrometry: a key analytical tool for the characterization of regioselectively derivatized maltooligosaccharides obtained starting from natural β-cyclodextrin.
  D. LESUR, A. GASSAMA, V. MOREAU, F. DJEDAINI-PILARD, A. BRIQUE, S. PILARD.
  Rapid Communications in Mass Spectrometry, 2005, Volume Date 2006, 20(5), 747-754.

• A use of modified cyclodextrins as a transporter for a radiolabeled tracer NMR investigation.
  Y. MICHEL, B. PERLY, F. DJEDAINI-PILARD, E. BERTHOMMIER, C. BAUDIN, C. FAJOLLES, B. HAMANN, R. PASQUALINI, L. MAUCLAIRE.
  Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2005, 51(3-4), 159-163.

• Preparation of amphiphilic amino acid-containing cyclodextrin derivatives.
  B. PERLY, S. MOUTARD, F. PILARD.
  Fr. Demande, 2005, 103 pp. FR 2861396 A1 20050429 Application: FR 2003-50736 20031024.

• Amphiphilic cyclodextrins - from a general concept to properties and applications.
  B. PERLY, S. MOUTARD, F. DJEDAINI-PILARD.
  PharmaChem, 2005, 4(1-2), 4-9.

• Synthesis of regioselectively and uniformly modified maltoheptaose derivatives from cyclomaltoheptaose precursors.
  D. LESUR, A. GASSAMA, V. MOREAU, S. PILARD, F. DJEDAINI-PILARD.
  Carbohydrate Research, 2005, 340(6), 1225-1231.

• Hydration of black foam films made of amphiphilic cyclodextrins.
  C. SULTANEM, S. MOUTARD, J.-J. BENATTAR, F. DJEDAINI-PILARD, B. PERLY.
  Langmuir : the ACS journal of surfaces and colloids, 2004, 20(8), 3311-8.

• Enhancement of vitamin A skin absorption by cyclodextrins.
  S. WEISSE, B. PERLY, C. CREMINON, F. OUVRARD-BARATON, F. DJEDAINI-PILARD.
  Journal of Drug Delivery Science and Technology, 2004, 14(1), 77-86.

• Skin compatibility of cyclodextrins and their derivatives: a comparative assessment using a corneoxenometry bioassay.
  G. PIEL, S. MOUTARD, E. UHODA, F. PILARD, G. PIERARD, B. PERLY, L. DELATTRE, B. EVRARD.
  European Journal of Pharmaceutics and Biopharmaceutics, 2004, 57(3), 479-482.

• Structural identification of new glycolipids based on cyclodextrin using high-resolution positive and negative electrospray ionization mass spectrometry.
  S. MOUTARD, F. DJEDAINI-PILARD, S. MEUDAL, W. LUIJTEN, B. PERLY, S. PILARD.
  Rapid Communications in Mass Spectrometry, 2003, 17(22), 2535-2540.

• Regioselective glycosylation of 3,6-unprotected mannoside derivatives: fast access to high-mannose type oligosaccharides.
  N. SMILJANIC, S. HALILA, V. MOREAU, F. DJEDAINI-PILARD.
  Tetrahedron Letters, 2003, 44(50), 8999-9002.

• A sensitive and specific enzyme immunoassay for the detection of methyl ether derivatives of cyclomaltoheptaose.
  F. DJEDAINI-PILARD, M.-C. NEVERS, S. WEISSE, J. GRASSI, B. PERLY, C. CREMINON.
  Carbohydrate Research, 2003, 338(20), 2091-2099.

• Novel glycolipids based on cyclodextrins.
  S. MOUTARD, B. PERLY, P. GODE, G. DEMAILLY, F. DJEDAINI-PILARD.
  Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2003, Volume Date 2002, 44(1-4), 317-322.

• New aqueous gel based on soluble cyclodextrin/vitamin A inclusion complex.
  S. WEISSE, B. PERLY, J.-P. DALBIEZ, F. BARATON-OUVRARD, J.-C. ARCHAMBAULT, P. ANDRE, P. ROLLIN, F. DJEDAINI-PILARD.
  Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2003, Volume Date 2002, 44(1-4), 87-91.

• Synthesis and characterization of mannosyl mimetic derivatives based on a β-cyclodextrin core.
  D. YOCKOT, M. MOREAU, G. DEMAILLY, F. DJEDAINI-PILARD.
  Organic & Biomolecular Chemistry, 2003, 1(10), 1810-1818.

• Recent developments in amphiphilic cyclodextrins: synthesis, characterization and properties.
  F. DJEDAINI-PILARD, R. AUZELY-VELTY, B. PERLY.
  Recent Research Developments in Organic & Bioorganic Chemistry, 2002, 5 41-57.

• Direct Investigation of the Vectorization Properties of Amphiphilic Cyclodextrins in Phospholipid Films.
  I. JAVIERRE, M. NEDYALKOV, V. PETKOVA, J.-J. BENATTAR, S. WEISSE, R. AUZELY-VELTY, F. DJEDAINI-PILARD, B. PERLY.
  Journal of Colloid and Interface Science, 2002, 254(1), 120-128.

• Cyclodextrin-induced lipid lateral separation in DMPC membranes: 2H nuclear magnetic resonance study.
  M. ROUX, R. AUZELY-VELTY, F. DJEDAINI-PILARD, B. PERLY.
  Biophysical Journal, 2002, 82(2), 813-822.

• Novel amphiphilic cyclodextrins: synthesis, characterization and properties.
  R. AUZELY-VELTY, J.-P. DALBIEZ, S. MOUTARD, B. PERLY, F. DJEDAINI-PILARD.
  Biologicheskii Zhurnal Armenii, 2001, 53(Iss. Spec.), 95-104.

• Pharmacological in vitro evaluation of new substance P-cyclodextrin derivatives designed to drug targeting towards NK1-receptor bearing cells.
  C. PEAN, A. WIJKHUISEN, F. DJEDAINI-PILARD, J. FISCHER, S. DOLY, M. CONRATH, J.-Y. COURAUD, J. GRASSI, B. PERLY, C. CREMINON.
  Biochim Biophys Acta Molecular Cell Research, 2001, 1541, 150-160.

• Amphiphilic cyclodextrins, their preparation and use for solubilizing and transporting hydrophobic molecules in aqueous media.
  R. AUZELY-VELTY, B. PERLY, F. DJEDAINI-PILARD.
  PCT Int. Appl., 2000, 51 pp. WO 2000066635 A1 20001109 Application: WO 2000-FR1102 20000426.

• Inclusion complexes of polyunsaturated fatty acids and their derivatives with γ-cyclodextrin.
  F. DJEDAINI PILARD, B. PERLY, J.-P. DALBIEZ, Q. MICHON, B. ROUSSEAU, P. BARRIER.
  PCT Int. Appl., 2000, 27 pp. WO 2000053637 A1 20000914 Application: WO 2000-FR560 20000307.

• Synthesis and characterization of peptidyl-cyclodextrins dedicated to drug targeting.
  C. PEAN, C. CREMINON, A. WIJKHUISEN, J. GRASSI, P. GUENOT, P. JEHAN, J.-P. DALBIEZ, B. PERLY, F. DJEDAINI-PILARD.
  Perkin 2, 2000, (4), 853-863.
• Reliable NMR experiments for the study of β-cyclodextrin/prostaglandin E2 inclusion complex.
  C. PEAN, C.CREMINON, A. WIJKHUISEN, B. PERLY, F. DJEDAINI-PILARD.
  Journal de Chimie Physique et de Physico-Chimie Biologique, 1999, 96(9/10), 1486-1493.

• A new specific enzyme immunoassay allowing an efficient pharmacokinetic evaluation of γ-cyclodextrin after intravenous administration to rats.
  C. CREMINON, F. DJEDAINI-PILARD, R. VIENET, C. PEAN, J.-M. GROGNET, J. GRASSI, B. PERLY, P. PRADELLES.
  Pharmaceutical Research, 1999, 16(9), 1407-1411.

• Cholesteryl-cyclodextrins: synthesis and insertion into phospholipid membranes.
  R. AUZELY-VELTY, B. PERLY, O. TACHE, T. ZEMB, P. JEHAN, P. GUENOT, J.-P. DALBIEZ, F. DJEDAINI-PILARD.
  Carbohydrate Research, 1999, 318(1-4), 82-90.

• In vitro and in vivo studies on the binding capacity of substance P-derived bifunctional ligands dedicated to drug targeting.
  A. WIJKHUISEN, C. PEAN, F. DJEDAINI-PILARD, J. FISCHER, M. CONRATH, R. SHIGEMOTO, J. GRASSI, B. PERLY, J.-Y. COURAUD, C. CREMINON.
  NATO Science Series, Series A: Life Sciences, 1999, 307(Peptidergic G Protein-Coupled Receptors), 157-160.

• NMR investigations of the inclusion of thyroxine and derivatives in natural cyclodextrins.
  C. PEAN, C. CREMINON, J. GRASSI, P. PRADELLES, B. PERLY, F. DJEDAINI-PILARD.
  Journal of Inclusion Phenomena and Macrocyclic Chemistry, 1999, 33(3), 307-319.

• Pharmacokinetic analysis of 6-monoamino-β-cyclodextrin after intravenous or oral administration to rats using a specific enzyme immunoassay.
  C. CREMINON, F. DJEDAINI-PILARD, R. VIENET, C. PEAN, J.-M. GROGNET, J. GRASSI, B. PERLY, P. PRADELLES.
  Journal of pharmaceutical sciences, 1999, 88(3), 302-5.

• New amphiphilic derivatives of cyclodextrins for the purpose of insertion in biological membranes: the "Cup and Ball" molecules.
  J. LIN, C. CREMINON, B. PERLY, F. DJEDAINI-PILARD.
  Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry, 1998, (12), 2639-2646.

• The hemolytic properties of chemically modified cyclodextrins.
  M. BOST, V. LAINE, F. PILARD, A. GADELLE, J. DEFAYE, B. PERLY.
  Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 1997, 29(1), 57-63.

• Cyclodextrins and their applications.
  B. PERLY, F. PILARD.
  Clefs CEA, 1997, 35 32-43.

• Enantioselectivity improvement induced by β-cyclodextrin in the NaBH4 reduction of acetophenone through the formation of a three-component inclusion β-cyclodextrin-acetophenone-triethylamine complex.
  A. DERATANI, E. RENARD, F. DJEDAINI-PILARD, B. PERLY.
  Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry, 1997, (8), 1517-1521.

• Use of cyclodextrins and their derivs. for solubilization of ginkgolides.
  J. DEFAYE, V. LAINE, F. DJEDAINI-PILARD, B. PERLY.
  Eur. Pat. Appl., 1997, 12 pp. EP 764659 A1 19970326 Application: EP 96-401982 19960918.

• Preparation of aminodeoxycyclodextrins and their use to incorporate hydrophobic molecules in organized surfactant systems.
  F. DJEDAINI-PILARD, J. LIN, B. PERLY.
  Eur. Pat. Appl. 1997, 11 pp. EP 751150 A1 19970102 Application: EP 96-401426 19960627.

• The respective benefits of NMR and mass spectrometry in the investigation of inclusion complexes of cyclodextrins. Application to the inclusion of ionic surfactants in β- and γ-cyclodextrins.
  J. LIN, F. DJEDAINI-PILARD, P. GUENOT, B. PERLY.
  Supramolecular Chemistry, 1996, 7(3), 175-181.

• Modification of the face selectivity in asymmetric induction by cyclodextrins through the formation of three-component inclusion compounds.
  E. RENARD, A. DERATANI, F. DJEDAINI-PILARD, B. PERLY.
  Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 1996, 25(1-3), 249-252.

• Inclusion complex of a radiohalogenated fatty acid in a cyclodextrin.
  R. PASQUALINI, B. PERLY, L. MAUCLAIRE, F. DJEDAINI-PILARD, Y. MICHEL.
  PCT Int. Appl., 1996, 25 pp. WO 9614881 A1 19960523 Application: WO 95-FR1489 19951113.

• Manufacture method and use of mono-3,6-anhydro-cyclodextrins for solubilizing hydrophobic compound and monitoring the purity of enantiomer.
  F. DJEDAINI-PILARD, B. PERLY.
  PCT Int. Appl., 1995, 24 pp. WO 9517433 A1 19950629 Application: WO 94-FR1502 19941221.

• Cyclodextrin derivatives for solubilizing hydrophobic chemical compounds such as drugs and method for their preparation.
  F. DJEDAINI-PILARD, N. AZAROUAL-BELLANGER, B. PERLY.
  PCT Int. Appl., 1995, 22 pp. WO 9517432 A1 19950629 Application: WO 94-FR1501 19941221.

• Use of aminocyclodextrins for the aqueous solubilization of dibenzazepine antiepileptics.
  F. DJEDAINI-PILARD, B. PERLY.
  PCT Int. Appl., 1995, 22 pp. WO 9517191 A1 19950629 Application: WO 94-FR1503 19941221.

• Inclusion and solubilization properties of 6-S-glycosyl-6-thio derivatives of β-cyclodextrin.
  V. LAINE, A. COSTE-SARGUET, A. GADELLE, J. DEFAYE, B. PERLY, F. DJEDAINI-PILARD.
  Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry, 1995, (7), 1479-87.

• A sensitive and specific enzyme immunoassay for cyclomaltoheptaose and some derivatives.
  C. CREMINON, F. PILARD, J. GRASSI, B. PERLY, P. PRADELLES.
  Carbohydrate Research, 1994, 258(1-2), 179-86.

• Synthesis of a new molecular carrier: N-(Leu-enkephalin)yl 6-amino-6-deoxy-cyclomaltoheptaose.
  F. DJEDAINI-PILARD, J. DESALOS, B. PERLY.
  Tetrahedron Letters, 1993, 34(15), 2457-60.

• Specific interaction and stabilization between host and guest: complexation of ellipticine in a nucleobase-functionalized cyclodextrin.
  F. DJEDAINI-PILARD, B. PERLY, S. DUPAS, M. MIOCQUE, H. GALONS.
  Tetrahedron Letters, 1993, 34(7), 1145-8.

• High field NMR techniques and molecular modeling study of the inclusion complexes of the nootropic drug Tenilsetam (CAS-997) in cyclodextrins.
  M. E. AMATO, F. DJEDAINI-PILARD, B. PERLY, G. SCARLATA.
  Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry, 1992, (11), 2065-9.

• Molecular modeling of β-cyclodextrin complexes with nootropic drugs.
  M. E. AMATO, F. DJEDAINI-PILARD, G. C. PAPPALARDO, B. PERLY, G. SCARLATA.
  Journal of Pharmaceutical Sciences, 1992, 81(12), 1157-61.

• Nuclear magnetic resonance investigation of the stoichiometries in β-cyclodextrin-steroid inclusion complexes.
  F. DJEDAINI, B. PERLY.
  Journal of Pharmaceutical Sciences, 1991, 80(12), 1157-61.

• High-accuracy measurement of proton chemical shifts and coupling constants in substituted cyclic oligosaccharides using phase-sensitive two-dimensional soft experiments.
  P. BERTHAULT, F. DJEDAINI, B. PERLY.
  Journal of Magnetic Resonance, 1991, 91(1), 102-12.

• Organic shift reagents for the NMR analysis of cyclodextrins.
  F. DJEDAINI, B. PERLY.
  Journal of Molecular Structure, 1990, 239 161-6. CODEN: JMOSB4 ISSN: 0022-2860.

• Intramolecular host-guest complexes of D- and L-mono-6-phenylalanyl-amino-6-deoxy cyclomalto-heptaoses.
  H. PARROT-LOPEZ, H. GALONS, A. W. COLEMAN, F. DJEDAINI, N. KELLER, B. PERLY.
  Tetrahedron: Asymmetry, 1990, 1(6), 367-70.

• Regio- and stereoselective deuterium labeling of β-cyclodextrin.
  F. DJEDAINI, J. DESALOS, B. PERLY.
  Journal of Labelled Compounds and Radiopharmaceuticals, 1990, 28(7), 785-91.

• Anthraquinonesulfonate as a general-purpose shift reagent for the NMR analysis of cyclodextrins.
  F. DJEDAINI, B. PERLY.
  Magnetic Resonance in Chemistry, 1990, 28(4), 372-4.

• High-field nuclear magnetic resonance techniques for the investigation of a β-cyclodextrin:indomethacin inclusion complex.
  F. DJEDAINI, S. Z. LIN, B. PERLY, D. WOUESSIDJEWE.
  Journal of Pharmaceutical Sciences, 1990, 79(7), 643-6.

• Conformation of the nootropic agents 1-(4-methoxybenzoyl)-5-oxo-2-pyrrolidinepropanoic acid (CI-933) and 4-hydroxymethyl-1-benzyl-pyrrolidin-2-one (WEB-1868): x-ray crystal structures, theoretical MO calculations (AM-1), and 600 MHz proton NMR spectra.
  M. E. AMATO, G. BANDOLI, F. DJEDAINI, A. DOLMELLA, A. GRASSI, G. PAPPALARDO.
  Journal of Molecular Structure, 1990, 222(3-4), 487-502.

• An approach to vectorization of pharmacologically active molecules: the covalent binding of Leu-enkephalin to a modified β-cyclodextrin.
  H. PARROT-LOPEZ, F. DJEDAINI, B. PERLY, A. W. COLEMAN, H. GALONS, M. MIOCQUE.
  Tetrahedron Letters, 1990, 31(14), 1999-2002.

• The use of circular dichroism for the determination of the absolute configuration of chiral butadiene-tricarbonyl iron complexes.
  F. DJEDAINI, D. GREE, J. MARTELLI, R. GREE, L. LEROY, J. BOLARD, L. TOUPET.
  Tetrahedron Letters, 1989, 30(29), 3781-4.

• Inclusion of spironolactone in cyclomaltoheptaose: a guest affected by the hospitality of the host.
  D. WOUESSIDJEWE, A. CRASSOUS, D. DUCHENE, A. W. COLEMAN, N. RYSANEK, G. TSOUCARIS, B. PERLY, F. DJEDAINI.
  Carbohydrate Research, 1989, 192 313-21.