Laboratoire des Glucides

FRE 3517

Accueil > Équipe BIOMOL > Albert Nguyen-Van-Nhien

Denis PostelMaître de Conférences
Mail : albert.nguyen-van-nhien@u-picardie.fr
Tel : 03 22 82 75 69
Fax : 03 22 82 75 60
C.V.

Membre de l'équipe BIOMOL

Description des travaux de recherche

Les travaux concernent l'étude de la réaction d'aminocyanation en série saccharidique et son implication dans l'élaboration de glycoaminoacides, de nucléosides modifiés et de façon plus large, à des composés hétérocycliques spiraniques.
De façon similaire l'utilisation des glyco-cyanomésylates obtenus à partir des différents cyanhydrines permet d'obtenir comme intermédiaire réactionnel des glyco-carbénoïdes et d'étudier leur application pour la préparation de composés polycycliques issus des réaction d'insertion de type C,H ou O,Si.
Ces deux types de composés sont également utilisés dans des réactions de type Staudinger-aza wittig afin d'obtenir des dérivés de type aminopyrrolidines.

Publications

  • Spiro-sulfamidate and sulfate nucleosides via 2' and 3'-C-branched-chain sugars and nucleosides J. Lalot, T. Tite, A. Wadouachi, D. Postel, N.A.N. Van, Tetrahedron 2011, 67 6006-6017.

  • Synthesis of variously coupled conjugates of D-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase
    By Kun, Sandor; Nagy, Gergo Z.; Toth, Marietta; Czecze, Laura; Nhien, Albert Nguyen Van; Docsa, Tibor; Gergely, Pal; Charavgi, Maria-Despoina; Skourti, Paraskevi V.; Chrysina, Evangelia D.; et al
    Carbohydrate Research 2011, 346(12), 1427-1438

  • Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV
    By Moura, Marina; Josse, Solen; Van Nhien, Albert Nguyen; Fournier, Carole; Duverlie, Gilles; Castelain, Sandrine; Soriano, Elena; Marco-Contelles, Jose; Balzarini, Jan; Postel, Denis
    European Journal of Medicinal Chemistry 2011, 46(10), 5046-5056.

  • Experimental and computational investigation of the unexpected formation of [beta]-substituted polyoxygenated furans from conveniently functionalized carbohydrates
    • Cordonnier, R.; Van Nhien, A. N.; Soriano, E.; Marco-Contelles, J.; Postel, D. Tetrahedron 2010, 66 (3), 736-742.
  • The synthesis of polyoxygenated, enantiomerically pure cyclopentane derivatives on route to neplanocin A stereoisomers via alkylidenecarbene species prepared from sugar templates
    • Nguyen Van Nhien, A.; Soriano, E.; Marco-Contelles, J.; Postel, D. Carbohydrate Research 2009, 344 (13), 1605-1611.
  • Highly functionalized, enantiomerically pure furo[x,y-c]pyrans via alkylidenecarbenes derived from sugar templates: synthesis and mechanism study via computational chemistry
    • Nguyen Van Nhien, A.; Cordonnier, R.; Le Bas, M.-D.; Delacroix, S.; Soriano, E.; Marco-Contelles, J.; Postel, D. Tetrahedron 2009, 65 (45), 9378-9394.
  • Synthesis of 2-aminocyclopropyl pyrrolidines from glycoaminonitriles.
    D. DECLERCK, S. JOSSE, A. NGUYEN-VAN-NHIEN, D. POSTEL.
    Tetrahedron Letters, 2009, 50 (19), 2171-2173.
  • Synthesis of 5-substituted-3,4-dihydroxycyanopyrrolidines. An easy access to polyhydroxyprolines.
    M. MOURA, S. DELACROIX, D. POSTEL, A. NGUYEN-VAN-NHIEN.
    Tetrahedron, 2009, 65 (14), 2766-2772.
  • A theoretical analysis of the Ti(IV)-catalyzed glycoaminocyanation reaction.
    E. SORIANO, J. MARCO-CONTELLES, H. DUCATEL, A. NGUYEN-VAN-NHIEN, D. POSTEL.
    Carbohydrate Research, 2008, 343 (10-11), 1835-1839.
  • Synthesis and anti-HIV1 biological activity of novel 5″-ATSAO compounds.
    C. TOMASSI,  A.  NGUYEN-VAN-NHIEN,  J. L.  MARCO-CONTELLES,  J. BALZARINI,  C. PANNECOUQUE,  E. DE CLERCQ, D. POSTEL.
    Bioorganic & Medicinal Chemistry, 2008, 16 (8), 4733-4741.
  • Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compounds.
    C. TOMASSI, A. NGUYEN-VAN-NHIEN, J.  L. MARCO-CONTELLES, J. BALZARINI, C. PANNECOUQUE, E. DE CLERCQ, E. SORIANO, D. POSTEL.
    Bioorganic & Medicinal Chemistry Letters, 2008, 18 (7), 2277-2281.
  • Novel glycine like amino acids from glyco-α-aminonitriles as building blocks for peptide synthesis.
    H. DUCATEL, A. NGUYEN-VAN-NHIEN., D. POSTEL.
    Tetrahedron: Asymmetry, 2008, 19(1), 67-81.
  • Efficient synthesis of sugar iminopyrrolidine derivatives via an intramolecular Staudinger-aza-Wittig-type reaction.
    H. DUCATEL, A. NGUYEN-VAN-NHIEN, S. PILARD, D. POSTEL.
    Synlett, 2006, (12), 1875-1878.
  • Computational Analysis of Aza Analogues of [2',5'-Bis-O-(tert-butyldimethylsilyl)-β -D-ribofuranose]-3'-spiro-5''- (4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) as HIV-1 Reverse Transcriptase Inhibitors: Relevance of Conformational Properties on the Inhibitory Activity.
    E. SORIANO, A. NGUYEN-VAN-NHIEN, C. TOMASSI, D. POSTEL, J. L. MARCO-CONTELLES.
    Journal of Chemical Information and Modeling, 2006, 46(4), 1666-1677. 
  • First Synthesis and Evaluation of the Inhibitory Effects of Aza analogues of TSAO on HIV-1 Replication.
    A. NGUYEN-VAN-NHIEN, J. BALZARINI, C. TOMASSI, C. LEN, J. L. MARCO-CONTELLES, C. PANNECOUQUE, E. DE CLERCQ, D. POSTEL.
    J. Med Chem., 2005, 48(13), 4276-4284.
  • Synthesis of 4-amino-5-H-dihydroisothiazole-1,1-dioxide ring system on sugar template via carbanion-mediated sulfonamide intramolecular cyclization reactions (CSIC protocols) of glyco-α-sulfonamidonitriles.
    L. DOMINGUEZ, A. NGUYEN-VAN-NHIEN, C. TOMASSI, C. LEN, D. POSTEL, J. L. MARCO-CONTELLES.
    J. Org. Chem., 2004, 69, 843.
  • Synthesis of 1,2-O-isopropylidene-3-spiro-(4’-amino-2’,3’-dihydro-1,1-dioxide-1’,2’-isothiazolyl) -D-ribo (or -D-allo)furanose derivatives, a series of key intermediates for the preparation of new, non-natural nucleoside.
    A. NGUYEN-VAN-NHIEN, L. DOMINGUEZ, C. TOMASSI, M. DEL ROSARIO TORRES, C. LEN, D. POSTEL, J. L. MARCO-CONTELLES.
    Tetrahedron, 2004, 60, 4709-4727.
  • Synthesis of AZA analogues of TSAO.
    A. NGUYEN-VAN-NHIEN, D. POSTEL, C. TOMASSI, C. LEN, J. L. MARCO-CONTELLES.
    Nucleosides, nucleotides & nucleic acids, 2003, 5-8, 943-945.
  • Chemistry of sulfonate and sulfonamide stabilized carbanions – The CSIC reaction,
    D. POSTEL, A. NGUYEN-VAN-NHIEN, J. L. MARCO-CONTELLES.
    Eur. J. Org.     Chem.    , 2003, 19, 3713-3726.
  • Glyco-α-aminonitriles as intermediates in organic synthesis.
    D. POSTEL, A. NGUYEN-VAN-NHIEN, C. LEN, H. DUCATEL, C. TOMASSI.
    Journal Marocain de Chimie Heterocyclique, 2002, 1(1), 1-6. 
  • Novel conformationally restricted glycoamino acids from glyco-α-aminonitriles as potent turn mimics in peptide synthesis. 
    D. POSTEL, A. NGUYEN-VAN-NHIEN, C. LEN, H. DUCATEL. 
    Tetrahedron Lett., 2002, 43(21), 3805-3808.
  • New 4-amino-5-H-2,3-dihydroisothiazole-1,1-dioxides from sugar
    α-aminonitriles using CSIC reaction.
    D. POSTEL, A. NGUYEN-VAN-NHIEN, P. VILLA, G. RONCO.
    Tetrahedron Lett.    , 2001, 42, 593-595.
  • Novel spirohydantoins of D-allose and D-ribose derived from glyco-α-aminonitriles.
    D. POSTEL, A. NGUYEN-VAN-NHIEN, P. VILLA, G. RONCO.
    Tetrahedron Lett., 2001, 42, 1499-1502.
  • Stereoseclective synthesis of α-aminonitriles at non-anomeric positions of monosaccharided.
    D. POSTEL, A. NGUYEN-VAN-NHIEN, M. PILLON, P. VILLA, G. RONCO.
    Tetrahedron Lett., 2000, 41, 6403-6406.
  • Preparation of oligosaccharide amino-nitriles via condensation of cyanide with imine derivatives.     
    D. POSTEL, A. NGUYEN-VAN-NHIEN, M. PILLON, P. VILLA, G. RONCO.
    Fr. Demande, 2000, 23 pp.  FR  2787453  A1  20000623  Application: FR  98-15861  19981216.
Haut de page
AccueilImprimerContactPlan du site/accèsCredits