• Synthèse de différents peptides cycliques (analogues ségétalines) et peptidomimétiques (ségétalines rigidifiées avec l’insertion d'un motif 2-oxopipérazine).
• Purification des peptides en chromatographie liquide haute performance.
• Analyse des molécules synthétisées au laboratoire (produits naturels et (spectromètre de masse QTOF Ultima Water).

Mots Clés :

Cyclopeptide, segetaline, SPPS, Spectrométrie de masse, CLHP

Publications

• P. Rouge, V. Silva-Pires, F. Gaboriau, A. Dassonville-Klimpt, J. Guillon, S. Da Nascimento, J. M. Léger, G. Lescoat, P. Sonnet.
Antiproliferative effect on HepaRG cellcultures of new calix[4]arenas. J. of Enz. Inh. Med. Chem. (2009); acceptée

• J. Pecher, V. Pires, I. Bechyne, S. Da Nascimento, F. Fauvel-Lafeve, C. Legrand, P. Sonnet. Circular dichroïsm studies of type III collagen mimetic peptides with anti- or pro-aggregant activities on human platelets European Journal of Medicinal Chemistry, (2009), 44(6), 2643-2650.

• S. C B Gnoatto, J. Guillon, A. Dassonville-Klimpt, S. Massip, S. Da Nascimento, G. Gosmann, P. Sonnet. Crystal structure of 3-O-acetyloleanolic acid. . Analytical Sciences, (2008), 24, x239-x240

• S. C B Gnoatto, L. D Vechia, C. L. Lencina, A. Dassonville, S. Da Nascimento, D. Mossalayi, G. Gosmann, P. Sonnet, Synthesis and Preliminary Evaluation of New Ursolic and Oleanolic Acids Derivatives as Antileishmanial Agents. Journal of Enzyme Inhibition and Medicinal Chemistry, (2008) (23) 604-610.

• S. C B Gnoatto, S. Susplugas, L. D Vechia, T. B. Ferreira, A. Dassonville, K. R. Zimmer, C. Demailly, S. Da Nascimento, J. Guillon, P. Grellier, H. Verli, G. Gosmann, P. Sonnet,     Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents. Bioorg. Med.  Chem., (2008) (16) 771-782.
• S. C. B. Gnoatto, A. Dassonville-Klimpt, S. Da Nascimento, P. Galéra, K. Boumediene, G. Gosmann, P. Sonnet, S. Moslemi
Evaluation of Ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition, European Journal of Medicinal Chemistry, (2008) (43), 1865-1877.

• V. Pires; J. Pecher; S. Da Nascimento; P. Maurice; A. Bonnefoy; C. Amant; F. Fauvel-Lafeve; C. Legrand; J. Rochette; P. Sonnet.
Type III collagen mimetic peptides designed with anti- or pro-thrombotic activities, European Journal of Medicinal Chemistry, (2007) (42) 694-70.

• V. Pires; François Gaboriau; Jean Guillon; Sophie Da Nascimento; Alexandra Dassonville; Gerard Lescoat; Jacques Rochette; Christian Jarry & Pascal Sonnet 
Modulation of cell proliferation in rat liver cell cultures by new calix[4]arenas. Journal of Enzyme Inhibition and Medicinal Chemistry (2006), 21 (3), 261-270

• Pascal Maurice; Viviane Pires; Carole Amant; Alexandre Kauskot; Sophie Da Nascimento; Pascal Sonnet; Jacques Rochette; Chantal Legrand; Françoise Fauvel-Lafeve and Arnaud Bonnefoy.      Antithrobontic effect of the type III collagen-related octapeptide (KOGEOGPK) in the mouse. Vascular Pharmacology  (2006), 44(1), 42-49.

• Nicolas Franceschini; Sophie Da Nascimento; Hugues Miel  and Pascal Sonnet Fast and chemoselective n-debenzylation route to chiral 2-substituted thiomorpholin-3-ones. Heterocyclic. Commun. (2005), 11(6), 509-512.

• Foulon Karine; Baltora-Rosset Sylvie; Fuentes Vincent; Mesnard François; Da Nascimento Sophie; Bouhassira E; Rochette Jacques.
Development of h1e histone linker-specific antibodies by means of synthetic pepdides. Journal of peptide Research (2004), 63(1), 1-8.

• Franceschini Nicolas; Da nascimento Sophie; Sonnet Pascal; Guillaume Dominique.
Efficient enantioselective synthesis of 2-substituted thiomorpholin-3-ones. Tetrahedron: Asymmetry (2003), 14(21), 3401-3405.

• Sonnet Pascal; Da Nascimento Sophie; Marty Danielle; Franceschini Nicolas; Guillon Jean; Brion Jean-Daniel; Rochette Jacques. 
First Synthesis of Segetalins B and G : two Cyclopentapeptides with Estrogen-like Activity. Tetrahedron Letters (2003), 44(16), 3293-3296.

• Pommier Blandine; Marie-Claire Cynthia; Da Nascimento Sophie; Wang HL; Roques Bernard P.; Noble Florence.
Further evidence that the CCK2 receptor is coupled to two transduction pathways using site-directed mutagenesis. Journal of Neurochemistry (2003), 85(2), 454-464

• Mas-Nieto Magdalena; Pommier Blandine; Tzavara Eleni T.; Caneparo Anne; Da Nascimento Sophie; Le Fur Gerard; Roques Bernard P.; Noble Florence.
Reduction of opioid dependence by the CB1 antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction. British Journal of Pharmacology (2001), 132(8), 1809-1816.

• Bellier Bruno; Million Marie-Emmanuelle; Da Nascimento Sophie; Meudal Herve; Kellou Safia; Maigret Bernard; Garbay Christiane. 
Replacement of glycine with dicarbonyl and related moieties in analogs of the C-terminal pentapeptide of cholecystokinin: CCK2 agonists displaying a novel binding mode. Journal of Medicinal Chemistry (2000), 43(20), 3614-3623.

• Chen Huixiong; Noble Florence; Mothe Aurelie; Meudal Herve; Coric Pascale; Da Nascimento Sophie; Roques Bernard P.; George Pascal; Fournie-Zaluski M.-Claude. 
Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities. Journal of Medicinal Chemistry (2000), 43(7), 1398-1408.

• Noble Florence.; Luciani Nathalie.; Da Nascimento Sophie.; Lai-Kuen René.; Bischoff Laurent.; Chen, Huixiong.; Fournie-Zaluski Marie.-Claude.; Roques Bernard. P.
Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography. FEBS Letters (2000), 467(1), 81-86.

• David Christelle; Bischoff Laurent; Meudal Herve; Mothe Aurelie; De Mota Nadia; Da Nascimento Sophie; Llorens-Cortes Catherine; Fournie-Zaluski Marie-Claude; Roques Bernard P.    Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme. Journal of Medicinal Chemistry (1999), 42(25), 5197-5211.

• Pommier Blandine; Da Nascimento Sophie; Dumont Stephanie; Bellier Bruno; Million Emmanuelle; Garbay Christiane; Roques Bernard P.; Noble Florence.
The cholecystokininB receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins. Journal of Neurochemistry (1999), 73(1), 281-288.

• Bellier Bruno; Da Nascimento Sophie; Meudal Herve; Gincel Edith; Roques Bernard P.; Garbay Christiane.
Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid. Bioorg. Med. Chem. Lett. (1998), 8(11), 1419-1424.

• Million Marie-Emmanuelle; Lena Isabelle; Da Nascimento Sophie; Noble Florence; Dauge Valerie; Garbay Christiane; Roques Bernard P.
Development of new potent agonists able to interact with two postulated subsites of the cholecystokinin CCK-B receptor. Lett. Pept. Sci. (1997), 4(4/5/6), 407-410.

• Bellier Bruno; McCort-Tranchepain Isabelle; Ducos Bertrand; Da Nascimento Sophie; Meudal Herve; Noble Florence; Garbay Christiane; Roques Bernard P.
Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of Two Affinity States of the CCK-B Receptor on Transfected CHO Cells. J. Med. Chem. (1997), 40(24), 3947-3956.